Hierarchical Self-Assembly of Amino Acid Derivatives into Enzyme-Responsive Luminescent Gel
نویسندگان
چکیده
In this study, a novel three-component hydrogel has been designed and fabricated via hierarchical self-assembly by amino acid derivative (N,N′-diphenylalanine-3,4,9,10-tetracarboxylic diimide (NPPD)), riboflavin (RF) and α-cyclodextrin (α-CD). These molecules were aggregated to form some fibrous structures based on hydrogen bond and π–π stacking. The results show that the hydrogel has a specific response to α-amylase and the fluorescence disappears once hydrolyzed. Therefore, this multi-component hydrogel has potential application in the field of drug delivery.
منابع مشابه
A Smart pH-Responsive Three Components Luminescent Hydrogel
In this study, we report a novel three-component luminescent hydrogel, which is composed of amino acid derivatives (N,N'-di valine-3,4,9,10-perylenetetracarboxylic acid, NVPD), riboflavin (RF), and melamine (MM). The three-component hydrogel is attributed to multiple hydrogen bonds and the strong π-π stacking interaction between these molecules. Based on the strong hydrogen bonding of the gelat...
متن کاملHierarchical self-assembly of a discrete hexagonal metallacycle into the ordered nanofibers and stimuli-responsive supramolecular gels.
A discrete hexagonal metallacycle decorated with multiple amide groups and long hydrophobic alkyl chains was constructed via [3+3] coordination-driven self-assembly, from which the ordered nanofibers and stimuli-responsive supramolecular gels were successfully obtained via hierarchical self-assembly.
متن کاملA Systematic Study on the Self-Assembly Behaviour of Multi Component Fmoc-Amino Acid-Poly(oxazoline) Systems
We report a systematic study of a modular approach to create multi-component supramolecular nanostructures that can be tailored to be both enzyme and temperature responsive. Using a straightforward synthetic approach we functionalised a thermal responsive polymer, poly(2-isopropyl-2-oxazoline), with fluorenylmethoxycarbonyl-amino acids that drive the self-assembly. Depending on the properties o...
متن کاملBio-functionalisation to enzymatically control the solution properties of a self-supporting polymeric material.
Molecular self-assembly permits the spontaneous aggregation of a variety of low molecular weight amino acid subunits into highly ordered aggregates. Functionalisation of water soluble poly(allylamine) with acetyl protected dialanine enables the formation of a biopolymer self-supporting material (SSM). The presence of an enzyme cleavable dipeptide linker renders the SSM responsive to disruption ...
متن کاملSynthesis and characterization of supramolecule self-assembly polyamidoamine (PAMAM) G1-G1 NH2, CO2H end group Megamer
Supramolecule self assembly polyamidoamine (PAMAM) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. These strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...
متن کامل